Opti Lab Research
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Research in the Human Performance Optimization Lab uses psychometric, neuroimaging, electrophysiological, neurostimulation, biophysiological modeling, and eye tracking approaches to understand the function of the human brain. We use statistical, computational, and experimental approaches to infer meaning from data. These methodologies are applied in both laboratory and real-world contexts to investigate the brain mechanisms that enable cognition and to develop interventions that speed learning and improve the quality of rehabilitation. Our 'Big Tent' research adheres to Open Science principles with pre-registered clinical trial, systematic reviews and meta-analyses with the goal of producing rigorous and impactful science. Specific areas of focus include:
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Clinical Cognitive Neuroscience
The field of cognitive neuroscience has revolutionized our ability to measure brain activity and connectivity while people behave and think in order to understand how physiology gives rise to psychology. By identifying the processes and mechanisms at work in healthy brains and determining how they are impaired in neuropsychiatric and neurologic patients, we are able to use this knowledge to create better diagnostic tools and more potent treatments. OptiLab research has embraced these goals with a particular emphasis on the use of network-neuroscience approaches to measure healthy and dysregulated brain activity with fMRI and EEG, and the application of targeted forms of Transcranial Magnetic Stimulation (TMS) with the goal of restoring healthy brain dynamics and optimal behavior. Optilab is in the fortunate position of contributing to the research mission of the UCSD Interventional Psychiatry Program where we facilitate many important clinical trials addressing disorders of mood and our research has been published in numerous articles including...
- Synaptic plasticity and mental health (Appelbaum et al 2022)
- TMS to enhance memory abilities in older adults (Beynel et al 2019; Beynel et al 2020; Beynel et al. 2020)
- TMS to improve emotional regulation (Powers et al 2020; Beynel et al 2020; 2018 DIBS Germinator)
- TMS treatment of substance use disorder (Young 2020; Addicott 2019; Young, Galla, and Appelbaum, 2021)
- Meta analysis of online rTMS (Beynel et al 2019)
- Systematic review of rTMS effects on fMRI resting-state functional connectivity (Beynel et al 2020)
This is what fMRI-guided, electric field-modeled, robot-controlled, brain stimulation looks like
Perceptual-Motor Learning and Expertise
Humans are remarkable at performing visually guided movements. We are able to achieve and master actions as simple as reaching for a cup and as complex as executing a bicycle kick in a soccer match. A great deal of our brain is devoted to this skill with rich multidirectional communication between systems that are responsible for visual perception, goal-oriented decision-making, and control of motor actions. Developing perceptual-motor expertise in highly demanding activities, such as competing in sports, conducting surgery, and performing music is accompanied by extensive reorganization in the nervous system and a major goal of the OptiLab has been to understand the nature of such perceptual-motor learning and expertise. Examples include:
- The physiology of errors in robotic surgery (D' Ambrosia et al 2023a; D' Ambrosia et al 2023b)
- Accelerating surgical skill learning (Cox et al, 2020; Liu et al 2020)
- Visual-motor expertise in athletes (Klemish, 2017; Burris et al, 2018; Liu et al 2020; Laby and Appelbaum, 2021; Ho et al 2023)
- Vision training in athletes (Appelbaum & Erickson 2016; Liu et al 2020; Appelbaum 2011, Appelbaum 2012)
- Biomarkers of shooting performance in immersive virtual reality (Liu et al 2021; Rao et al, 2018)
- Edited Special Issues:
- Optometry and Vision Science, Special Issue "Visual Function and Sports Performance"
- Frontiers in Human Neuroscience, Research Topic, "Neural Mechanisms of Perceptual-Cognitive Expertise in Elite Performers"
Strobe Training
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Rhodes Information Initiative DATA+ project with USA Baseball
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Vision training with basketball Team
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Sports Vision Library
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Mechanisms of Visual Cognition
Vision plays a central role in the way we perceive, locomote, conceptualize, and remember the world around us. This experience is built from sensory inputs that create perceptual representations, selective attention that prioritizes processing of some elements over others, working memory to maintain and manipulate this information in our mind, and executive functions that decide what to respond to and how. Research in OptiLab seeks to understand how the brain creates these abilities, seemingly without effort. To gain this knowledge we combine psychometric measurement of behavior combined with advanced methods for recording the activity and connectivity of the brain to create a detailed mechanistic account of behavior and the physiology that enables visual cognition. Examples include:
- The brain mechanism of precise timing (Stoltz et al 2023)
- fMRi BOLD, resting-state and functional connectivity studies of working memory (Davis et al 2018; Crowell et al 2020)
- "Frequency-tagged" EEG to study scene perception (Appelbaum et al 2006; 2008; 2009; 2010; 2012; Norcia et al 2015)
- Reward influences on attention and decision making (San Martin 2013; San Martin 2015)
- The mechanisms of executive control in the brain (Appelbaum et al. 2009; 2012; 2014; Donohue et al 2016; Krebs et al. 2013)
- Multisensory integration (Donohue et al. 2013; Appelbaum et al. 2013)
- Response inhibition (Boehler et al. 2010; 2011; 2012)